Design and properties of pharmaceutical supramolecular systems

About the group:

Development of drugs with modified properties and improved delivery system is an urgent task of pharmaceutical chemistry. The main attention is paid to the development of innovative long-acting drugs with high bioavailability and minimal undesirable side effects. Supramolecular complexes on the basis of cyclodextrins and biopolymers in which pharmacologically active agent is retained by noncovalent interactions are proposed for preparation of these novel pharmaceutical formulations

 

 

Research area:

- complex formation of macrocyclic receptors and biopolymers with drugs and biologically active compounds;

- solvent effects (pH, presence of biologically active inorganic salts) in molecular complex formation;

- novel dosage forms based on the supramolecular complexes of biolmolecules with macrocycles and biopolymers;

- solubilization and prolonging the activity of drugs by complexation with cyclodextrins and biopolymers

Projects, Grants Laboratory:

Grant of Russian Science Foundation (№15-13-10017, 2015) - Development of new drug compounds with neuroprotective and cognitive-stimulating properties on the basis of supramolecular chemistry approaches

 

Grant of Russian Foundation for Basic Research (№15-43-03017, 2015) - Development and investigation of new water-soluble dosage forms of disease-modifying antirheumatic drugs

 

Grant of Ministry of Education and Science of the Russian Federation"Research and scientific-pedagogical personnel of innovative Russia for 2009-2013." (№8839, 2012-2013) – Study on effects of biologically relevant inorganic salts on encapsulation of drugs and vitamins by cyclodextrins: thermodynamic study.

 

Grant of Russian Foundation for Basic Research (№12-03-97516, 2012-2014) - Study on the influence of components of biological environment on encapsulation of drugs by cyclodextrins

 

Grant of Russian Foundation for Basic Research (№09-03-97563, 2009-2012) - Thermodynamic study on possibility to use cyclodextrins as encapsulating materials for flavins with the purpose to enhance their biological and pharmacological activity

 

Grant of Russian Foundation for Basic Research (№06-03-96313, 2006-2009) - Thermodynamic aspects of possibility of improving of physicochemical properties and activity of some drugs due to their complex formation with cyclodextrins

 

Grant of Russian Foundation for Basic Research (№03-03-96411, 2003-2005) - Physical and chemical investigation of possibility of modification of some drugs and vitamins by means of clathration with cyclodextrins
Agafonov Mikhail Andreevich
Ph.D. student
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Chibunova Ekaterina
Ph.D. student
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Kritsky Ilya Leonidovich
Ph.D. student
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Terekhova Irina Vladimirovna
Leading researcher
Doctor of сhemical sciences
Lecturer (docent)
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  1. Terekhova I.V., Tikhova M.N., Volkova T.V., Kumeev R.S., Perlovich G.L. Inclusion complex formation of a- and b-cyclodextrins with riboflavin and alloxazine in aqueous solution: thermodynamic study // Journal of Inclusion Phenomena and Macrocyclic Chemistry. – 2011. – V.69. – №1-2. – P.167-172.
  2. Terekhova I.V., Koźbiał M., Kumeev R.S., Alper G.A. Inclusion complex formation between modified cyclodextrins and riboflavin and alloxazine in aqueous solution // Journal of Solution Chemistry. – 2011. – V.40. – №8. – P.1435-1446.
  3. Terekhova I.V., Koźbiał M., Kumeev R.S., Gierycz P. Complex formation of native and hydroxypropylated cyclodextrins with benzoic acid in aqueous solution: volumetric and 1H NMR study // Chemical Physics Letters. – 2011. – V.514. – №4-6. – P.341-346.
  4. Terekhova I.V. Comparative thermodynamic study on complex formation of native and hydroxypropylated cyclodextrins with benzoic acid // Thermochimica Acta. – 2011. – V.526. –  №1-2. – P.118-121.
  5. Usacheva T.R., Sharnin V.A., Chernov I.V., Matteoli E., Terekhova I.V., Kumeev R.S. The influence of water-ethanol mixture on the thermodynamics of complex formation between 18-crown-6 and L-phenylalanine // Chemical Physics Letters. – 2012. – V.543. – P.155-158.
  6.  Terekhova I.V., Chibunova E.S., Kumeev R.S., Alper G.A. Role of biologically active inorganic anions Cl- and Br- in inclusion complex formation of a-cyclodextrin with some aromatic carboxylic acids // Chemical Physics Letters. – 2013. – V.557. – P.134-139.
  7.  Romanova A.O., Chibunova E.S., Kumeev R.S., Fedorov M.V., Terekhova I.V. a-Cyclodextrin/aminobenzoic acid binding in salt solutions at different pH: dependence on guest structure // International Journal of Biological Macromolecules. – 2013. – V.57. – P.255-258.
  8. Terekhova I.V., Chibunova E.S., Kumeev R.S., Alper G.A. Cyclodextrin-benzoic acid binding in salt solutions: Effects of biologically relevant anions // Carbohydrate Polymers – 2014. – V. 110. – P. 472-479.
  9. Terekhova I.V., Chibunova E.S., Kumeev R.S., Kruchinin S.E., Fedotova M.V., Kozbiał M., Wszelaka-Rylik M., Gierycz P. Specific and nonspecific effects of biologically active inorganic salts on inclusion complex formation of cyclodextrins with aromatic carboxylic acids // Chemical Engineering Science. – 2015. – V. 122. – P. 97-103.
  10. Usacheva T.R., Pham Thi L., Terekhova I.V., Kumeev R.S., Sharnin V.A. Application of isothermal titration calorimetry for evaluation of water-acetone and water-dimethylsulfoxide solvent influence on the molecular complex formation between 18-crown-6 and triglycine at 298.15 K // Journal of Thermal Analysis and Calorimetry. – 2015. – V. 121. – P. 975-981.
  11. Chibunova E.S., Kumeev R.S., Terekhova I.V. Thermodynamic study on salt effects on complex formation of α-, β- and γ-cyclodextrins with p-aminobenzoic acid // J. Chem. Thermodyn. – 2015.– V. 91. – P. 30-34.
Dissolution tester DT-8000
Анализатор
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UNICO SpectroQuest 2800
UV/VIS спектрофотометр УФ и видимой области
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