Design and properties of pharmaceutical supramolecular systems

About the group:

Development of drugs with modified properties and improved delivery system is an urgent task of pharmaceutical chemistry. The main attention is paid to the development of innovative long-acting drugs with high bioavailability and minimal undesirable side effects. Supramolecular complexes on the basis of cyclodextrins and biopolymers in which pharmacologically active agent is retained by noncovalent interactions are proposed for preparation of these novel pharmaceutical formulations

 

 

Research area:

- complex formation of macrocyclic receptors and biopolymers with drugs and biologically active compounds;

- solvent effects (pH, presence of biologically active inorganic salts) in molecular complex formation;

- novel dosage forms based on the supramolecular complexes of biolmolecules with macrocycles and biopolymers;

- solubilization and prolonging the activity of drugs by complexation with cyclodextrins and biopolymers

Projects, Grants Laboratory:

Grant of Russian Science Foundation (№15-13-10017, 2015) - Development of new drug compounds with neuroprotective and cognitive-stimulating properties on the basis of supramolecular chemistry approaches

 

Grant of Russian Foundation for Basic Research (№15-43-03017, 2015) - Development and investigation of new water-soluble dosage forms of disease-modifying antirheumatic drugs

 

Grant of Ministry of Education and Science of the Russian Federation"Research and scientific-pedagogical personnel of innovative Russia for 2009-2013." (№8839, 2012-2013) – Study on effects of biologically relevant inorganic salts on encapsulation of drugs and vitamins by cyclodextrins: thermodynamic study.

 

Grant of Russian Foundation for Basic Research (№12-03-97516, 2012-2014) - Study on the influence of components of biological environment on encapsulation of drugs by cyclodextrins

 

Grant of Russian Foundation for Basic Research (№09-03-97563, 2009-2012) - Thermodynamic study on possibility to use cyclodextrins as encapsulating materials for flavins with the purpose to enhance their biological and pharmacological activity

 

Grant of Russian Foundation for Basic Research (№06-03-96313, 2006-2009) - Thermodynamic aspects of possibility of improving of physicochemical properties and activity of some drugs due to their complex formation with cyclodextrins

 

Grant of Russian Foundation for Basic Research (№03-03-96411, 2003-2005) - Physical and chemical investigation of possibility of modification of some drugs and vitamins by means of clathration with cyclodextrins

Leading researcher
Doctor of сhemical sciences
Lecturer (docent)
  1. Books

    1. Terekhova I.V. salt effects on the inclusion complex formation of cyclodextrins with some biologically active aromatic carboxylic acids / Cyclodextrins: synthesis, chemical applications and role in drug delivery. ed. F.G. Ramirez.- Nova Science Publishers. -USA, New York 2015. P. 269.

    2. Terekhova I.V. Study on riboflavin encapsulation by cyclodextrins  / Advances in Medicine and Biology. Volume 81; ed. L. V. Berhardt.- Nova Science Publishers. - USA, New York. 2014. P.129.

    3. Terekhova I.V. Inclusion complex formation of cyclodextrins with aminobenzoic acids in aqueous solution // Ch. 8 in Macrocyclic Chemistry: New Research Developments. Eds. D.W. Fitzpatrick and H.J. Ulrich. Nova Science Publishers. -USA, New York. 2010. Р.263.

    Papers:

    1. Agafonov M., Volkova T., Kumeev R., Chibunova E., Terekhova I. Impact of pluronic F127 on aqueous solubility and membrane permeability of antirheumatic compounds of different structure and polarity // Journal of Molecular Liquids. 2019. 274. 770-777.

    2. Kritskiy I., Volkova T., Surov A., Terekhova I. γ-Cyclodextrin-metal organic frameworks as efficient microcontainers for encapsulation of leflunomide and acceleration of its transformation into teriflunomide // Carbohydrate Polymers. 2019. 216. 224-230.

    3. Volkova T., Kumeev R., Kochkina N., Terekhova I. Impact of Pluronics of different structure on pharmacologically relevant properties of sulfasalazine and methotrexate // Journal of Molecular Liquids. 2019. 289. 111076.

    4. Volkova T.V., Domanina E.N., Kumeev R.S., Proshin A.N., Terekhova I.V. The effect of different polymers on the solubility, permeability and distribution of poor soluble 1,2,4-thiadiazole derivative // Journal of Molecular Liquids. 2018. 269. 492-500.

    5. Kritskiy I., Kumeev R., Volkova T., Shipilov D., Kutyasheva N., Grachev M., Terekhova I. Selective binding of methotrexate to monomeric, dimeric and polymeric cyclodextrins // New Journal of Chemistry. 2018. 42. 14559-14567.

    6. Volkova T.V., Chibunova E.S., Silyukov,O.I., Proshin A.N., Terekhova I.V. Impact of biorelevant media on pharmacologically important properties of potential neuroprotectors based on 1,2,4-thiadiazole // Journal of Molecular Liquids. - 2017. - V.247. - P.64-69

    7. Volkova T.V., Perlovich G.L., Terekhova I.V. Enhancement of dissolution behavior of antiarthritic drug leflunomide using solid dispersion methods // Thermochimica Acta. - 2017. - V.656. - P.123-128.

    8. Brusnikina M.A., Silyukov,O.I., Chislov M.V., Volkova T.V., Proshin A.N., Mazur A.S., Tolstoy P.M., Terekhova I.V. Effect of cyclodextrin complexation on solubility of novel anti-Alzheimer 1,2,4-thiadiazole derivative // Journal of Thermal Analysis and Calorimetry. - 2017. - V.130. - P.443-450.

    9. Brusnikina M.A., Silyukov,O.I., Chislov M.V., Volokova T.V., Proshin A.N., Terekhova I.V. New water-soluble dosage forms of 1,2,4-thiadiazole derivative on the basis of inclusion complexes with cyclodextrins //  Journal of Thermal Analysis and Calorimetry. - 2017. - V.127. - P.1815-1824.

    10. Chislov М.В., Brusnikina  M.А., Chibunova E.S., Volkova T.V., Zvereva I.A., Proshin A.N., Terekhova I.V. Thermodynamics and binding mode of novel structurally related 1,2,4-thiadiazole derivatives with native and modified cyclodextrins // Chemical Physics Letters. - 2017. - V.671. - P.28-36.

    11. Brusnikina M.A., Chibunova E.S., Silyukov O.I., Chislov M.V., Volkova T.V., Proshin A.N., Terekhova I.V. Selective interactions of cyclodextrins with isomeric 1,2,4-thiadiazole derivatives displaying pharmacological activity: Spectroscopy study // Journal of Solution Chemistry. - 2017. - V.46. - P.1970-1980.

    12. Terekhova I., Kumeev R., Alper G., Chakraborty S., Pérez-Sánchez H., Núñez-Delicado E. Molecular recognition of aromatic carboxylic acids by hydroxypropyl-γ-cyclodextrin: experimental and theoretical evidence // RSC Advances – 2016. – V.6. – P.49567

    13. Terekhova I.V., Chibunova E.S., Kumeev R.S., Kruchinin S.E., Fedotova M.V., Kozbiał M., Wszelaka-Rylik M., Gierycz P. Specific and nonspecific effects of biologically active inorganic salts on inclusion complex formation of cyclodextrins with aromatic carboxylic acids // Chemical Engineering Science. – 2015. – V. 122. – P. 97-103.

    14. Usacheva T.R., Pham Thi L., Terekhova I.V., Kumeev R.S., Sharnin V.A. Application of isothermal titration calorimetry for evaluation of water-acetone and water-dimethylsulfoxide solvent influence on the molecular complex formation between 18-crown-6 and triglycine at 298.15 K // Journal of Thermal Analysis and Calorimetry. – 2015. – V. 121. – P. 975-981.

    15. Chibunova E.S., Kumeev R.S., Terekhova I.V. Thermodynamic study on salt effects on complex formation of α-, β- and γ-cyclodextrins with p-aminobenzoic acid // J. Chem. Thermodyn. – 2015.– V. 91. – P. 30-34.

Анализатор
UV/VIS спектрофотометр УФ и видимой области