Terekhova Irina Vladimirovna

Position: 
Leading researcher
Degree: 
Doctor of сhemical sciences
Academic title: 
Lecturer (docent)
Phone: 
+7 (4932) 351859
His research interests:

Supramolecular complexes of macrocyclic ligands and biopolymers with biologically active compounds and drugs

 

Participation in grants and programs:

Grant of Russian Science Foundation (№15-13-10017, 2015) - Development of new drug compounds with neuroprotective and cognitive-stimulating properties on the basis of supramolecular chemistry approaches

 

Grant of Russian Foundation for Basic Research (№15-43-03017, 2015) - Development and investigation of new water-soluble dosage forms of disease-modifying antirheumatic drugs

 

Grant of Ministry of Education and Science of the Russian Federation"Research and scientific-pedagogical personnel of innovative Russia for 2009-2013." (№8839, 2012-2013) – Study on effects of biologically relevant inorganic salts on encapsulation of drugs and vitamins by cyclodextrins: thermodynamic study.

 

Grant of Russian Foundation for Basic Research (№12-03-97516, 2012-2014) - Study on the influence of components of biological environment on encapsulation of drugs by cyclodextrins

 

Grant of Russian Foundation for Basic Research (№09-03-97563, 2009-2012) - Thermodynamic study on possibility to use cyclodextrins as encapsulating materials for flavins with the purpose to enhance their biological and pharmacological activity

 

Grant of Russian Foundation for Basic Research (№06-03-96313, 2006-2009) - Thermodynamic aspects of possibility of improving of physicochemical properties and activity of some drugs due to their complex formation with cyclodextrins

 

Grant of Russian Foundation for Basic Research (№03-03-96411, 2003-2005) - Physical and chemical investigation of possibility of modification of some drugs and vitamins by means of clathration with cyclodextrins

The most important publications:

Books

 

1. Terekhova I.V. salt effects on the inclusion complex formation of cyclodextrins with some biologically active aromatic carboxylic acids / Cyclodextrins: synthesis, chemical applications and role in drug delivery. ed. F.G. Ramirez.- Nova Science Publishers. -USA, New York 2015. P. 269.

2. Terekhova I.V. Study on riboflavin encapsulation by cyclodextrins  / Advances in Medicine and Biology. Volume 81; ed. L. V. Berhardt.- Nova Science Publishers. - USA, New York. 2014. P.129.

3. Terekhova I.V. Inclusion complex formation of cyclodextrins with aminobenzoic acids in aqueous solution // Ch. 8 in Macrocyclic Chemistry: New Research Developments. Eds. D.W. Fitzpatrick and H.J. Ulrich. Nova Science Publishers. -USA, New York. 2010. Р.263.

Papers

1. Zielenkiewicz W., Terekhova I.V., Wszelaka-Rylik M., Kumeev R.S. Thermodynamics of inclusion complex formation of hydroxypropylated α- and β-cyclodextrins with aminobenzoic acids in water // Journal of Thermal Analysis and Calorimetry. – 2010. – V.101. – №1. – P.15-23.

2. Zielenkiewicz W., Terekhova I.V., Koźbiał M., Kumeev R.S. Thermodynamic study on complex formation of riboflavin with hydroxypropyl-b-cyclodextrin in water // Journal of Thermal Analysis and Calorimetry. – 2010. – V.101. – №2. – P.595-600.

3. Terekhova I.V., Hammitzsch-Wiedemann M., Shi Y., Sungthong B., Scriba G.K.E. Investigation of the pH-dependent complex formation between b-cyclodextrin and peptide enantiomers by capillary electrophoresis and calorimetry // Journal of Separation Science. – 2010. – V.33. – №16. – P.2499-2505.

4. Terekhova I.V., Romanova A.O., Kumeev R.S., Fedorov M.V. Selective Na+/K+ effects on the formation of a-cyclodextrin complexes with aromatic carboxylic acids: competition for the guest // Journal of Physical Chemistry B. – 2010. – V.114. – №39. – P.12607-12613.

5. Terekhova I.V., Tikhova M.N., Volkova T.V., Kumeev R.S., Perlovich G.L. Inclusion complex formation of a- and b-cyclodextrins with riboflavin and alloxazine in aqueous solution: thermodynamic study // Journal of Inclusion Phenomena and Macrocyclic Chemistry. – 2011. – V.69. – №1-2. – P.167-172.

6. Terekhova I.V., Koźbiał M., Kumeev R.S., Alper G.A. Inclusion complex formation between modified cyclodextrins and riboflavin and alloxazine in aqueous solution // Journal of Solution Chemistry. – 2011. – V.40. – №8. – P.1435-1446.

7. Терехова И.В., Кумеев Р.С., Альпер Г.А., Агафонов А.В. Термодинамические характеристики реакций образования комплексов a- и b-циклодекстринов с люмихромом, люмазином и урацилом в водном растворе // Журнал физической химии. – 2011. – Т.85. – №10. – С.1977-1982.

8. Terekhova I.V., Koźbiał M., Kumeev R.S., Gierycz P. Complex formation of native and hydroxypropylated cyclodextrins with benzoic acid in aqueous solution: volumetric and 1H NMR study // Chemical Physics Letters. – 2011. – V.514. – №4-6. – P.341-346.

9. Terekhova I.V. Comparative thermodynamic study on complex formation of native and hydroxypropylated cyclodextrins with benzoic acid // Thermochimica Acta. – 2011. – V.526. –  №1-2. – P.118-121.

10. Usacheva T.R., Sharnin V.A., Chernov I.V., Matteoli E., Terekhova I.V., Kumeev R.S. The influence of water-ethanol mixture on the thermodynamics of complex formation between 18-crown-6 and L-phenylalanine // Chemical Physics Letters. – 2012. – V.543. – P.155-158.

11. Terekhova I.V., Chibunova E.S., Kumeev R.S., Alper G.A. Role of biologically active inorganic anions Cl- and Br- in inclusion complex formation of a-cyclodextrin with some aromatic carboxylic acids // Chemical Physics Letters. – 2013. – V.557. – P.134-139.

12. Romanova A.O., Chibunova E.S., Kumeev R.S., Fedorov M.V., Terekhova I.V. a-Cyclodextrin/aminobenzoic acid binding in salt solutions at different pH: dependence on guest structure // International Journal of Biological Macromolecules. – 2013. – V.57. – P.255-258.

13. Terekhova I.V., Chibunova E.S., Kumeev R.S., Alper G.A. Cyclodextrin-benzoic acid binding in salt solutions: Effects of biologically relevant anions // Carbohydrate Polymers – 2014. – V. 110. – P. 472-479.

14. Terekhova I.V., Chibunova E.S., Kumeev R.S., Kruchinin S.E., Fedotova M.V., Kozbiał M., Wszelaka-Rylik M., Gierycz P. Specific and nonspecific effects of biologically active inorganic salts on inclusion complex formation of cyclodextrins with aromatic carboxylic acids // Chemical Engineering Science. – 2015. – V. 122. – P. 97-103.

15. Usacheva T.R., Pham Thi L., Terekhova I.V., Kumeev R.S., Sharnin V.A. Application of isothermal titration calorimetry for evaluation of water-acetone and water-dimethylsulfoxide solvent influence on the molecular complex formation between 18-crown-6 and triglycine at 298.15 K // Journal of Thermal Analysis and Calorimetry. – 2015. – V. 121. – P. 975-981.

16. Chibunova E.S., Kumeev R.S., Terekhova I.V. Thermodynamic study on salt effects on complex formation of α-, β- and γ-cyclodextrins with p-aminobenzoic acid // J. Chem. Thermodyn. – 2015.– V. 91. – P. 30-34.

main stages of research and teaching:

Ivanovo State University, Department of Chemistry and Biology

2000 – PhD, Chemistry, candidate thesis

2013 – PhD, Chemistry, doctoral thesis

 

Collaboration

Institute of Physical Chemistry of Polish Academy of Sciences (Warsaw, Poland)

Department of Physical Chemistry of the University of Palermo (Palermo, Italy)

Department of Pharmaceutical Chemistry of University of Jena (Jena, Germany)

Strathclyde University (Glasgow, UK)