Наиболее важные публикации 2016-2020 г.
Термодинамика, растворы, сольватация, межмолекулярные взаимодействия
- Barannikov V.P., Kurbatova M.S., Mezhevoi I.N. The influence of structure of isomolecular dipeptides of α-L-alanyl-α-L-alanine and β-alanyl-β-alanine on their behavior in aqueous micellar solution of SDS. // Thermochimica Acta, 2020, V.689, 178647 https://doi.org/10.1016/j.tca.2020.178647
- Smirnov V. I., Badelin V. G., Barannikov V. P.,Kurbatova M. S. Influence of the compositon of (H2O + SDS) mixtures on interaction energy of DL-α-alanyl-D L-α-valine and DL-α-alanyl-DL-α-norleucine with SDS micelles at T=298.15 K // Journal of Solution Chemistry, 2019, (2019) 48:1309–1317 https://doi.org/10.1007/s10953-019-00910-1
- Barannikov V.P., Guseynov S.S. Effect of Solvent Polarity on Enthalpies of Solvation of Ethylene Oxide Oligomers // Journal of Chemical & Engineering Data, 2020, 5, 5, 2784-2789 https://dx.doi.org/10.1021/acs.jced.0c00098
- Tyunina E.Yu., Badelin V.G., Mezhevoi I.N. Volumetric and heat capacity studies of heterocyclic compounds in aqueous amino acids buffer solutions at 298.15 K // Journal of Chemical Thermodynamics. 2019. Vol. 131. P. 40-48.
- Smirnov V. I. Thermochemical investigation of L-glutamine dissolution processes in aqueous co-solvent mixtures of acetonitrile, dioxane, acetone and dimethyl sulfoxide at T=298.15 K. // J. Chem. Thermodyn. 150 (2020). https://doi.org. :10.1016/j.jct.2020.106227
- Smirnov V.I., Badelin V.G. The effect of the side chain structures on the energy of intermolecular interactions of α-amino acids with some formamides in aqueous solutions at T = 298.15 K. // J. Mol. Liquids 275 (2019) 474–477. https://doi.org/10.1016/j.molliq.2018.11.065
- Smirnov V.I., Badelin V.G. Similarity and differences of the thermochemical charac-teristics of L-glutamine dissolution in aqueous solutions of some acetamides and forma-mides at T = 298.15 K. // J. Mol. Liquids 285 (2019) 84–88. https://doi.org/10.1016/j.molliq.2019.04.099
- Smirnov V.I., Badelin V.G. Influence of the composition of aqueous-alcohol solvents on enthalpic characteristics of L-glutamine dissolution at T = 298.15. // J. Mol. Liquids 258 (2018) 253–257. https://doi.org/10.1016/j.molliq.2018.03.013
- Smirnov V.I., Badelin V.G. Thermodynamic Parameters of the Dissolution of 4- Hydroxy-L-Proline and L-Phenylalanine in Mixed Aqueous Solvents at 298 K. Russ. // J. Phys. Chem. A. 92/1 (2018) 93–98. https://link.springer.com/article/10.1134/S0036024417120287
- Mezhevoi I.N., Badelin V.G. Thermochemical analysis of intermolecular interactions of N-acetylglycine with polyols in aqueous solutions // Russian Journal of Physical Chemistry A, 2017. Vol.91. № 5. P. 810-813
- Smirnov V.I., Badelin V.G. Influence of N-methyl substitution in the glycine molecule on its enthalpic dissolution characteristics in mixed aqueous-amide solvents at T = 298.15 K. // J. Mol. Liquids 255 (2018) 471–475. https://doi.org/10.1016/j.molliq.2018.01.124
- Smirnov V.I., Badelin V.G. Thermochemical characteristics of 4-OH-L-proline and L-proline dissolution in (H2O + alcohol) mixtures at T=298.15 K. // J. Mol. Liquids 229 (2017) 198–202. http://dx.doi.org/10.1016/j.molliq.2016.12.025
- Smirnov V.I., Badelin V.G. Thermodynamic characteristics of trans-4-hydroxy-L-proline dissolution in some (water + amide) mixtures at T=298.15 K.// Thermochim. Acta 653 (2017) 27-31. http://dx.doi.org/10.1016/j.tca.2017.03.022
- Smirnov V.I., Badelin V.G. Influence of the composition of aqueous-amide solvents on enthalpic characteristics of L-proline dissolution at T= 298.15 K.// J. Mol. Liquids 220 (2016) 21–25. http://dx.doi.org/10.1016/j.molliq.2016.04.033
- Smirnov V.I., Badelin V.G. V.I. Smirnov, V.G. Badelin. Thermochemical Characteristics of the Dissolution of D-Valine in Aqueous Solutions of Some Amides at T = 298.15 K. // J. Chem. Ing. Data. 89 (2016) 1593-1780. http://dx.doi.org/10.1021/acs.jced.5b01087
- E.V. Ivanov, A.V. Kustov, D.V. Banov, N.L. Smirnova, N.L. Pechnikova. Thermodynamics of tetramethylurea solutions in ethylene glycol: The evidence of pairwise solvophobic interaction // J. Mol. Liq. 317 (2020) 113994. https://doi.org/10.1016/j.molliq.2020.113994.
- E.V. Ivanov, E.Yu. Lebedeva. On the similarity in some thermodynamic properties of N-dimethylureas and their bis-derivatives as solutes in water // J. Mol. Liq. 310 (2020) 113134. https://doi.org/10.1016/j.molliq.2020.113134.
- E.V. Ivanov, E.Yu. Lebedeva, D.V. Batov, V.V. Baranov, A.N. Kravchenko. Equimolecular co-crystal of cis- and trans-coordinated N,N’-dimethylglycolurils: some standard thermodynamic properties in the aqueous solution between 278.15 K and 318.15 K // J. Mol. Liq. 297 (2020) 111891. https://doi.org/10.1016/j.molliq.2019.111891.
- E.V. Ivanov, A.V. Kustov, E.Yu. Lebedeva. Volume-related solvation and pair interaction parameters for dilute solutions of urea and tetramethylurea in ethylene glycol between 288.15 K and 328.15 K: A comparative analysis // J. Chem. Thermodyn. 135 (2019) 336-344. https://doi.org/10.1016/j.jct.2019.04.009.
- E.V. Ivanov, D.V. Batov. Unusual behavior of temperature-dependent solvent H/D-isotope effects in the enthalpy and heat capacity of hexamethylenetetramine hydration // J. Mol. Liq. 285 (2019) 508-514, https://doi.org/10.1016/j.molliq. 2019.04.104.
- E.V. Ivanov, A.V. Kustov, E.Yu. Lebedeva. Solutions of urea and tetramethylurea in formamide and water: a comparative analysis of volume characteristics and solute – solute interaction parameters at temperatures from (288.15 to 328.15) K and ambient pressure // J. Chem. Eng. Data. 64 (2019) 5886-5899. http://dx.doi.org/10.1021/acs.jced.9b00794.
- E.V. Ivanov, E.Yu. Lebedeva. Effect of solvent isotopic substitution and temperature on some standard thermodynamic properties of tetramethylthiourea in H2O and D2O: A comparison with aqueous oxygen-containing analogue // J. Mol. Liq. 272 (2018) 361-368. https://doi.org/10.1016/j.molliq. 2018.08.143.
- E.V. Ivanov. Standard volumetric properties of chiral N-methyl-substituted glycolurils in water between 278.15 and 318.15 K at ambient pressure // J. Chem. Eng. Data 63 (2018) 2766-2774. https://doi.org/10.1021/acs.jced.8b00105.
- E.V. Ivanov, E.Yu. Lebedeva, A.N. Kravchenko. Standard volumetric properties of a chiral pharmaceutical Albicar in water H/D isotopologues in the temperature range from (278.15 to 318.15) K and at ambient pressure // J. Chem. Thermodyn. 115 (2017) 148-155. http://dx.doi.org/10.1016/j.jct.2017.07.034.
- E.V. Ivanov, E.Yu. Lebedeva, S.G. Petrovskaya, V.V. Baranov, A.N. Kravchenko, N.G. Ivanova. Volume-related interaction parameters for dilute solutions of Mebicaret (2,4-dimethyl-6,8-diethylglycoluril) in normal and heavy water between 278.15 K and 318.15 K // J. Mol. Liq. 242 (2017) 160-167. https://doi.org/10.1016/j.molliq.2017.07.003.
- E.V. Ivanov, D.V. Batov. Enthalpies and heat capacities of solution of racemic N-methyl-substituted glycolurils in water at T = (278.15 to 313.15) K // Thermochim. Acta 620 (2015) 69-54. http://dx.doi.org/10.1016/j.tca.2015.09.023.
- E.V. Ivanov, D.V. Batov, V.V. Baranov, A.V. Kravchenko. Temperature-dependent thermochemical properties of Mebicaret (2,4-dimethyl-6,8-diethylglycoluril) solutions in H2O and D2O at the ambient pressure // Thermochim. Acta 627 (2016) 48-54. http://dx.doi.org/10.1016/j.tca.2016.01.010.
- E.V. Ivanov, D.V. Batov. Effect of the H/D solvent isotope substitution on enthalpy-related interaction parameters in aqueous solutions of the racemic Albicar at T = 298.15 K and ambient pressure // J. Chem. Thermodyn. 102 (2016) 9-11. http://dx.doi.org/10.1016/j.jct.2016.06.020.
- E.V. Ivanov E.V., E.Yu. Lebedeva. Standard volumetric characteristics of N-dimethyl-substituted bicyclic bisureas (glycolurils) in water at T = (278.15 to 318.15) K and p ~ 0.1 MPa // J. Mol. Liq. 222 (2016) 1164-1171. http://dx.doi.org/10.1016/j.molliq.2016.07.131.
- V. P. Barannikov and S. S. Guseinov. Thermodynamic Functions of Solvation of 1,4-Dioxane in Various Solvents at 298.15 K. // Russian Journal of Physical Chemistry A, 2014, Vol. 88, No. 2, pp. 252–256. (Zhurnal Fizicheskoi Khimii, 2014, Vol. 88, No. 2, pp. 269–273). http://link.springer.com/article/10.1134/S0036024414020058
Компьютерное моделирование взаимодействия пептидов с мицеллярными системами
- Barannikov V.P., Kurbatova M.S., Gurina D.L., Giricheva N.I. Quantum chemical and molecular dynamics modeling of interaction of isomolecular dipeptides of α-l-alanyl-α-l-alanine and β-alanyl-β-alanine with sodium dodecyl sulfate micelles // Computational and Theoretical Chemistry, 2020, V.1182, 112844 https://doi.org/10.1016/j.comptc.2020.112844
- Barannikov V.P., Kurbatova M.S., Giricheva N.I. Quantum-Chemical Modeling of the Interaction of Carnosine and Anserine Dipeptides with Sodium Dodecyl Sulfate Dimer as a Fragment of Anionic Micelle // Journal of Structural Chemistry, 2021, DOI 10.26902/JSC_id68306
- Giricheva N.I., Kurbatova M.S., Tyunina E.Yu., Barannikov V.P. Quantum-chemical modeling of the interaction of leucine with a dimer of sodium dodecyl sulfate // Journal of Structural Chemistry, 2018, Vol.59, No.8, P.1768-1775, DOI: 10.1134/S0022476618080024
Кислотно-основные равновесия
- Lytkin A. I., Barannikov V. P., Badelin V. G., Krutova O. N. Enthalpies of acid dissociation of L-carnosine in aqueous solution // Journal of Thermal Analysis and Calorimetry, 2020, 139:3683–3689 https://doi.org/10.1007/s10973-019-08604-y
- A.I. Lytkin, O.N. Krutova, V.G. Badelin, E.Yu. Tyunina, A.A. Golubev. Effect of the nature of background electrolyte on the thermodynamic characteristics of the acid-base reactions of L-asparagine in aqueous solutions. // Russ. J. Phys. Chem. A. 2019. Vol. 93. No.9. P. 1729-1732. DOI 10.1134/S0036024419080193
- A.I. Lytkin, V.G. Badelin, O.N. Krutova, E.Yu. Tyunina, P.D. Krutov. Thermochemistry of the acid-base interactions in aqueous solutions of isonicotinic and picolonic acids. // Russ. J. Gen. Chem. 2019. Vol. 89. No. 11. P. 2235-2238. DOI: 10.1134/S1070363219110124
- Lytkin A. I., Chernikov V.V., Krutova O. N., Badelin V. G., Barannikov V. P. Thermodynamic Characteristics of Acid–Base Reactions in Aqueous Solutions of DL-α-Alanyl-DL-norleucine // Russian Journal of Physical Chemistry A, 2018 92(10), p. 1907-1910; DOI 10.1134/S0044453718100187
- Kochergina L.A., Krutova O.N., Volkov A.V., Damrina K.V., Badelin V.G. Standard enthalpies of formation for glycyl-tyrosine and products of its dissociation in aqueous solutions // Russian Journal of Physical Chemistry A. 2015. Т. 89. № 7. С. 1223-1226. http://link.springer.com/article/10.1134/S0036024415070171
- Kochergina L.A., Krutova O.N., Badelin V.G. Standard enthalpies of dissolution of L-tryptophan and the formation of its dissociation products in aqueous solutions at 298.15 K // Russian Journal of Physical Chemistry A. 2014. Т. 88. № 5. С. 790-793. http://link.springer.com/article/10.1134/S0036024414050148
- V. G. Badelin, V. P. Barannikov, A. V. Katrovtseva, and G. N. Tarasova. Dissociation Constants of Protolytic Dissociation of Glutamyl-Glutamic and Glycyl-Glutamic Acids in Aqueous Solution at 298 K. // Russian Journal of General Chemistry, 2013, Vol. 83, No. 5, pp. 945–948. (Zhurnal Obshchei Khimii, 2013, Vol. 83, No. 5, pp. 809–812). http://link.springer.com/article/10.1134/S1070363213050113
- V. G. Badelin, V. P. Barannikov, G. N. Tarasova, N. V. Chernyavskaya, A. V. Katrovtseva, and Fam Tkhi Lan. Thermodynamical Characteristics of Acid_Base Equilibria in Glycyl-Glycyl-Glycine Aqueous Solutions at 298 K. // Russian Journal of Physical Chemistry A. 2012. Т. 86. № 1. С. 40-44. http://link.springer.com/article/10.1134/S003602441112003X
Взаимодействия биоактивных веществ с коферментом и органическими соединениями
- Barannikov V.P., Venediktov E.A. Constants of Interaction between Pyridoxal-5'-Phosphate Coenzyme and Glycine and Its Oligopeptides in Aqueous Buffered Saline // Russian Journal of Physical Chemistry A, 2020, Vol. 94, No. 11, pp. 1678–1680 DOI: 10.1134/S0036024420110035
- E.V. Ivanov, D.V. Batov. Enthalpy-related parameters of interaction of the simplest a-amino acids with mebicar (N-tetramethylglycoluril) in water at 298.15 K // J. Chem. Thermodyn. 128 (2019) 159-163. https://doi.org/10.1016/j.jct.2018.08.022.
- E.Yu. Tyunina, V.G. Badelin, A.A. Kuritsyna. Molecular interactions of L-histidine in an aqueous buffer solution in the temperature range of 288-313 K. // Russ. J. Phys. Chem. A. 2020. Vol. 94. No. 4. P. 731-737. DOI: 10.1134/S0036024420040226
- E.Yu. Tyunina, O.N. Krutova, A.I. Lytkin. Determination of the complexation parameters of L-asparagine with some biologically active pyridine derivatives in aqueous solutions from calorimetric results. // Thermochimica Acta. 2020. Vol. 690. P. 178-704. https://doi.org/10.1016/j.tca.2020.178704
- E.Yu. Tyunina, V.G. Badelin, I.N. Mezhevoi. Observation of complex formation between L-histidine and heterocyclic compounds in water and aqueous buffer solution using calorimetric and spectroscopic methods. // Journal of Molecular Liquids. 2019. Vol. 278. P. 505-511. https://doi.org/10.1016/j.molliq.2019.01.092
- E.Yu. Tyunina, V.G. Badelin, I.N. Mezhevoi. Study on interaction of nicotinic acid with L-phenylalanine in buffer solution by heat capacity measurements at various temperatures. // J. Solution Chem. 2017. Vol. 46. No. 2. P. 249-258. DOI 10.1007/s10953-017-0570-6
- V. P. Barannikov, V. G. Badelin, E. A. Venediktov, I. N. Mezhevoi, and S. S. Guseinov. Thermodynamical Characteristics of the Reaction of Pyridoxal-5'-Phosphate with L-Amino Acids in Aqueous Buffer Solution. // Russian Journal of Physical Chemistry A, 2011, Vol. 85, No. 1, pp. 16–20.( Zhurnal Fizicheskoi Khimii, 2011, Vol. 85, No. 1,pp. 20–24). http://link.springer.com/article/10.1134/S003602441101002X; http://elibrary.ru/item.asp?id=15599189
- E.Yu. Tyunina, V.G. Badelin, I.N. Mezhevoi, G.N. Tarasova, Thermodynamics of aromatic amino acids interactions with heterocyclic ligands. // Journal of Molecular Liquids. 2015. Vol. 211. P. 494-497. http://dx.doi.org/10.1016/j.molliq.2015.07.024
- E.Yu. Tyunina, V.G. Badelin, Interaction of L-Phenylalanine with Nicotinic Acid in Buffer Solution by Volumeric Measurements at Various Temperatures. // J_Solution_Chem. 2016. Vol. 45. No.3. P.475-482. http://dx.doi.org/10.1007/s10953-016-0451-4
- I.N. Mezhevoi., V.G. Badelin Energetics of the molecular interactions of L-alanine and L-serine with xylitol, D-sorbitol, and D-mannitol in aqueous solutions at 298,15 K // Russian Journal of Physical Chemistry A. 2013. Vol. 87. N 4. P. 589-592. (Zhurnal Fizicheskoi Khimii 2013. Vol. 87. N 4. P. 610-614). http://link.springer.com/article/10.1134/S0036024413040183
- V.G. Badelin, E.Yu. Tyunina, I.N. Mezhevoi, G.N. Tarasova Thermodynamic characteristics of molecular interactions between L-tryptophan and nicotinic acid and uracyl in aqueous buffer solutions at 298 K // Russian Journal of Physical Chemistry A. 2015. Vol. 89. N 12. P. 2229-2233. (Zhurnal Fizicheskoi Khimii 2015. Vol. 89. N 12. P. 1884-1888). http://link.springer.com/article/10.1134/S0036024415120031
- Tyunina E.Yu., Badelin V.G., Tarasova G.N. Interactions of aromatic amino acids with heterocyclic ligands: An IR spectroscopic study. // Russ. J. Phys. Chem. A. 2015. Vol.89. No.9. P.1595-1598 (Zhurnal Fizicheskoi Khimii 2015. Vol. 89. N 9. P. 1407-1410) https://link.springer.com/article/10.1134/S0036024415080300
- Barannikov V.P., Guseinov S.S., V'ugin A.I. Molecular complexes of crown ethers in crystals and solutions. // Russian Journal of Coordination Chemistry. 2002. V. 28. № 3. P. 153-162 (Koordinatsionnaya Khimiya, Vol. 28, No. 3, 2002, pp. 163–172). http://link.springer.com/article/10.1023/A%3A1014729400394
Сублимация
- E.Yu. Tyunina, I.N. Mezhevoi, V.V. Dunaeva. Thermodynamic properties of crystalline L-carnosine and its aqueous solutions. // J. Chem. Thermodynamics. 2020. Vol. 150. P. 106-206. https://doi.org/10.1016/j.jct.2020.106206
- V.V. Tyunina, A.V. Krasnov, E.Yu. Tyunina, V.G. Badelin, V.V. Rybkin. Enthalpies of sublimation of L-methionine and DL-methionine: Knudsen’s effusion mass spectrometric study. // J. Chem. Thermodynamics. 2019. Vol. 135. P. 287-295. https://doi.org/10.1016/j.jct.2019.04.006
- Badelin V.G., Tyunina V.V., Girichev G.V., Tyunina E.Yu. Relationship between molecular descriptors and the enthalpies of sublimation of natural amino acids. // Russ. J. Phys. Chem. 2016. Vol.90. No.7. P.1306-1311 (Zhurnal Fizicheskoi Khimii 2016. Vol.90. N. 7. P. 980-985). https://link.springer.com/article/10.1134/S0036024416070037; http://elibrary.ru/item.asp?id=26160871
- Tyunina V.V., Krasnov A.V., Girichev G.V., Badelin V.G. Enthalpy of sublimation of hydroxyl-containing amino acids: knudsen's effusion mass spectrometric study // The Journal of Chemical Thermodynamics. 2016. Т. 98. С. 62-70. http://dx.doi.org/10.1016/j.jct.2016.02.021
- V.V. Tyunina, A.V. Krasnov, E.Yu. Tyunina, V.G. Badelin, G.V. Girichev. Enthalpy of sublimation of natural aromatic amino acids determined by Knudsen’s effusion mass spectrometric method. // J. Chem. Thermodynamic. 2014. Vol.74. P.221-226. http://dx.doi.org/10.1016/j.jct.2014.02.003
- Tyunina E.Yu., Badelin V.G. Sublimation effects and volume effects in the crystals of amino acids, peptides, and their some acetyl derivatives // Russian journal of general chemistry. 2013. V.83. No.4. p.708-716 (Zhurnal Fizicheskoi Khimii, 2013. Т. 83. № 4. С. 624-633). http://link.springer.com/article/10.1134/S1070363213040178; http://elibrary.ru/item.asp?id=18888925
- V.K. Abrosimov, A.V. Krasnov, Yu.A. Zhabanov, E.V. Ivanov. The molecule structure and sublimation enthalpy for 2,4,6,8-tetramethylglycoluril being the “mebicar” pharmaceutical // Russ. J. Chem. Chem. Technol. 58/1 (2015) 3-5. http://journals.isuct.ru/ctj/ (ISSN 0579-2991)
Процессы переноса в растворах
- E.Yu. Tyunina, M. D. Chekunova, Electrochemical properties of LiAsF6 solutions in a mixed solvent propylene carbonate - acetonitrile // Russ. J. Electrochem. 2019. Vol. 55. P. 122-131. DOI 10.1134/S1023193519010142
- E.Yu. Tyunina, M. D. Chekunova, Physicochemical properties of binary solutions of propylene carbonate – acetonitrile in range of 253.15 – 313.15 K. // Russ. J. Phys. Chem. A. 2017. Vol. 91. No. 5. P. 894-900. (Zhurnal Fizicheskoi Khimii 2017. Vol. 91. N 5. P. 845-851) DOI: 10.1134/S0036024417050260
- E. Tyunina, V. Afanas`ev, M. Chekunova. Viscosity and Density of Solutions of Tetraethylammonium Tetrafluoroborate in Propylene Carbonate at Different Temperatures. // J. Solution Chem. 2012. Vol. 41. No.2. P. 307-317. https://link.springer.com/article/10.1007/s10953-012-9793-8
- E.Yu. Tyunina, M.D. Chekunova. Electrochemical properties of lithium hexafluoroarsenate in methyl acetate at various temperatures. // J. Mol. Liq. 2013. Vol. 187. P. 332-336. http://dx.doi.org/10.1016/j.molliq.2013.08.019
- E.Yu. Tyunina, V.N. Afanasiev, M.D. Chekunova. Electroconductivity of tetraethylammonium tetrafluoroborate in propylene carbonate at various temperatures. // J. Chem. Eng. Data. 2011. Vol. 56. N 7. P. 3222-3226. http://dx.doi.org/10.1021/je200309v
Термический анализ, сольваты, полиморфизм
- Surov O. V., Voronova M. I., Barannikov V. P., Shaposhnikov G. P. Structural Features and Thermal Stability of 25,26,27,28-Tetrahydroxycalix[4]arene Molecular Complexes with Solvents. The Journal of Physical Chemistry С. 2014. V.118. No1. P.338-345. http://pubs.acs.org/doi/ipdf/10.1021/jp409003f
- Surov O. V., Voronova M. I., Barannikov V. P. Drastic and subtle thermally and gas-induced transformations of pure 4-tert-butylcalix[4]arene. CrystEngComm. 2014. V.16. Iss.37. P.8700-8705. http://pubs.rsc.org/en/content/articlehtml/2014/ce/c4ce01156b
- M. I. Voronova, O. V. Surov, S. S. Guseinov, V. P. Barannikov, A. G. Zakharov. Thermal stability of polyvinyl alcohol/nanocrystalline cellulose composites. // Carbohydrate Polymers. 2015, 130 (2015) 440–447. http://dx.doi.org/10.1016/j.carbpol.2015.05.032
- В.Г. Баделин, Е.Ю. Тюнина, И.Н. Межевой. Термогравиметрическое исследование ароматических аминокислот и алифатических пептидов. // Жидкие кристаллы и их практическое использование. 2014. Т. 14. №3. С. 43-52. http://elibrary.ru/item.asp?id=22502026