The equilibrium solubility of climbazole (CLZ), an antifungal drug, was determined in buffers (pH 2.0; 7.4), hexane and 1-octanol within the temperature range 293.15–313.15 K. The measured solubility of the compound was correlated by the van’t Hoff equation, modified Apelblat equation and two-suffix Margules model. Hansen solubility parameters show that 1-octanol and hexane can be considered relatively good solvents and water is a poor solvent for the drug studied. The molar heat capacity for CLZ was measured near the melting temperature. The theoretical ideal solubilities, activity coefficients and thermodynamic functions of dissolution and solvation of the drug were estimated. The temperature dependence of the CLZ partition coefficients were determined in a 1-octanol/buffer pH 7.4 system. The thermodynamic functions of the compound transfer from water to organic phase derived using partition coefficients and calculated based on the solvation parameters were in good agreement.
