The experimental and theoretical study to improvement solubility of griseofulvin using DESs of composition choline chloride/urea and choline chloride/PEG-300 with DES mass fraction 0.0 – 1.0 in aqueous solutions at 298.15–313.15 K was carried out. The solubility of the drug increases with the addition of DES and temperature growth. The obtained results demonstrate the great potential of polymeric DES as a solubilizer of the studied drug providing solubility value 18.46 mmol·L−1 at 298.15 K. The interactions between the DES’s components and the drug were studied by performing FTIR analysis. The miscibility of GSF with the DESs studied was assessed based on Hansen solubility parameters. The temperature dependences of the density of the used DES aqueous solutions were determined. ChCl/PEG DES, which has a lower density compared to ChCl/urea, was found to be a better solvent for GSF. Finally, thermodynamic analysis of GSF dissolution process in DES aqueous solutions is presented.
