Enthalpies of dissolution of glycyl-L-tyrosine in the mixtures of water with methanol (MeOH), ethanol
(EtOH), propanol (1-PrOH), 2-propanol (2-PrOH), acetonitrile (AN), 1,4-dioxane (DO),acetone (AN),
dimethylsulfoxide (DMSO), formamide (FA), N-methylformamide (NMF), N,N-dimethylformamide (DMF)
and N,N-dimethylacetamide (DMA) have been measured at 298.15 K. The standard enthalpies of the
solution (ΔsolH∘) and transfer (ΔtrH∘) of glycol-L-tyrosine from water into aqueous solution of organic cosolvents as well as the enthalpy coefficients of pairwise interaction (hxy) have been calculated. The interrelation between the enthalpy characteristics of dissolution (transfer) of glycyl-L-tyrosine and the composition of aqueous organicmixtures was established. Contributions of the organic co-solvent properties (molar volume, cohesion energy density, dipolarity/polarizability, acidity and basicity) to the energy of pairwise interactions were estimated quantitatively by means of a modified Kamlet–Taft equation. Some characteristics of intermolecular interactions of glycyl-L-tyrosine with the molecules of organic co-solvents with the analogous characteristics of glycylglycine and diglycylglycine were compared.
