In this paper, the sensitivity of new fluorescent sensors based on zinc(II) bis(dipyrromethenate)s ([Zn2L2]s) to the furosemide presence in organic media is described. It has been shown that the instantaneous spectral response of [Zn2L2]s to the furosemide presence is based on the fluorescence quenching effect. Multi-approach analysis (UV–vis and fluorescent titrations, PXRD, FTIR, 1H NMR, DOSY, and DFT calculations) has shown that the [Zn2L2]s fluorescence quenching is associated with the formation of stable [Zn2L2Fur]s supramolecular systems, capable of photoinduced electron transfer. The furosemide detection limit with using [Zn2L2]s was 65–78 μg L−1. The proposed sensors can be used for the forensic, clinical and sports medicine needs.
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