This work is aimed at obtaining and studying thermosensitive hydrogels based on a combination of Pluronics with different structures for the development of a controlled delivery system for leflunomide. Compared to gels based solely on F127, binary gels demonstrate variability in properties. To a greater extent, the mechanical properties of the gels are determined by the total mass of Pluronics in the composition rather than the polymer type. Combinations of Pluronics F127, F68 and L64 enable precise control of the sol-gel transition temperature. It is established that the incorporation of leflunomide into the gels lowers their gelation temperature, which is associated with the micelle dehydration due to solubilization. The processes of leflunomide release from the gels in a buffer solution and a biorelevant medium simulating synovial fluid are investigated. Composites with prolonged action are identified, and the relationship between the drug release rate and the rheological parameters of the gels is demonstrated.
