Pharmacologically important physicochemical properties were determined for carbendazim, albendazole and fenbendazole. Solubility in buffers (pH 2.0 and pH 7.4), hexane, and octanol was measured by the shake flask method between 293.15 and 313.15 K. All compounds were shown to be poor soluble in pH 7.4 and hexane; better solubility in octanol was revealed. A pronounced effect of pH on the solubility was detected. The Hansen solubility parameters showed the consistency with the experimental data. The thermodynamic functions of dissolution and transfer processes demonstrated low driving forces of the transition of carbendazim from buffer pH 7.4 to hexane and from buffer pH 2.0 to octanol, and albendazole from buffer pH 2.0 to hexane. The distribution of the studied compounds in octanol/buffer pH 2.0 and hexane/buffer pH 2.0 systems demonstrated the compliance with the transferring thermodynamics. Permeability coefficients indicated the influence of molecule charge state and size on the transition through the Permeapad (TM).
