Date of publication: June 14, 2022.
Scientific advisor: Perlovich German Leonidovich, Doctor of Chemical Sciences, Professor, Head of laboratory at ISC RAS.
Date of defense: October 06, 2022.
Supervising organization: Kazan Federal University.
The work is devoted to solving an urgent problem of establishing the regularities in the effects of molecular structure, composition and crystalline structure of cocrystals, polymorphic and pseudo-polymorphic species of organic drug compounds on the solubility of the latter in aqueous media; determining the interrelation between the structure of single- and multicomponent crystalline species and thermodynamic characteristics of sublimation, fusion and dissolution.
The author has developed new theoretical approaches to studying single- and multicomponent molecular crystals to show the interrelation between the molecular structure, composition and crystalline structure of cocrystals, polymorphic and pseudo-polymorphic species of organic drug compounds and solubility, thermodynamic characteristics of sublimation, fusion and dissolution of the latter.
He has also proved the efficiency of the approach based on changing the molecular packaging of the active pharmaceutical ingredient in terms of increasing the solubility of drug compounds.
The work describes new approaches to evaluating thermodynamic stability and solubility of multicomponent crystalline phases based on the analysis of crystallochemical and thermophysical characteristics and parameters of solubility of individual compounds.
The author has shown the prospects for using a complex experimental and theoretical methodology in studying crystalline structures in order to identify the key intermolecular interactions responsible for stabilizing multicomponent crystals and a variety of polymorphic modifications.
