Manin Alexey Nikolaevich

Position: 
Senior Researcher
Degree: 
Phd in chemistry
Phone: 
+7 (4932) 336990
E-mail: 
anm@isc-ras.ru
Subdivision: 
Laboratory of design of multicomponent crystalline forms for pharmaceutical purposes
Awards and honors:
  1. Winner of the Grant of Russian Science Foundation for initiative researches by young scientists 2017
  2. Diploma-recipient of the Government of the Ivanovo Region for a high level of research and development and a significant contribution to the development of the scientific and innovative sphere of the Ivanovo Region. 2016
  3. Winner of the scholarship competition of the President of the Russian Federation for state support of young Russian scientists - candidates of sciences 2015.
  4. Winner of the Grant of the President of the Russian Federation for supporting young scientists 2013
  5. First prize on VIII All-Russian school-conference of young scientists “Theoretical and experimental chemistry of liquid-phase systems”, Ivanovo, Russia, 2013.
  6. First prize on Students and post-graduate students all-Russian competition of research in the field of chemistry and material sciences in the National Festival of Science, Kazan for research work “Development of promising drugs with improved solubility by cocrystallization technology”, 2011
  7. 1st degree poster prize on V All-Russian conference of students and post-graduate students with international participation “Chemistry in modern world”, Saint-Petersburg, 2011.
  8. First prize, XI International conference “Problem of solvation and complex formation in solutions”; VI All-Russian school-conference of young scientists “Theoretical and experimental chemistry of liquid-phase systems”, Ivanovo, Russia, 2011.
  9. Scholarship of Academician G. N. Krestov, G.A. Krestov Institute of Solution Chemistry, Russian Academy of Sciences. 2010
  10. IUPAC Poster prize at the 14th International symposium on Solubility Phenomena & Related Equilibrium Phenomena (ISSP-14), Leoben, Austria, 2010.
  11. First prize students and post-graduate students research works competition for research work “Pharmaceutical cocrystal screening optimization”, Moscow, 2010
  12. First prize on V Regional young scientist conference “Theoretical and experimental chemistry of liquid-phase systems”, Ivanovo, Russia, 2010.
Research interests:

• Physical chemistry of drugs,

• Design of pharmaceutical co-crystals,

• Drug-drug co-crystals

• Crystal lattice energy experimental evaluation,

• Study of drug solubility enhancement methods

Participation in grants and programs:
  • Participant of the grant of Russian Science Foundation № 19-13-00017. ”Fundamental and applied aspects of creation of bioavailable antifungal drugs”. 2019-2021
  • Participant of the grant of Russian Science Foundation № 19-73-10005. “Design and investigation of new multicomponent crystalline forms of anthelmintic drugs. Combination of experimental approach and molecular modeling methods”. 2019-2022
  • Project manager of the grant of Russian Science Foundation № 17-73-10351. “Development of new formulations of antibacterial drug compounds on the basis of multicomponent molecular crystals”. 2017-2019.
  • Participant of the grant of Russian Foundation for Basic Research № 16-53-150007. «Design of crystalline forms of drug compounds using supercritical
  • fluid technology: Polymorphism and co-crystals» 2016-2018
  • Participant of the grant of Russian Foundation for Basic Research № 14-03-00009 A. “Multifunctional pharmaceutical systems for photodynamic therapy of cancer: synthesis, stability, solubility and distribution in biologically active environments”. Russia 2014-2016.
  • Participant of the grant of Russian Science Foundation №14-13-00640. “Development of basic knowledge base for creation of new generation of bioavailable drugs using cocrystal technology exemplified by antituberculous compounds”. Russia 2014-2016.
  • Participant of the grant of Russian Foundation for Basic Research № 14-03-31001 mol_a. “Pharmaceutical co-crystals: preparation and physicochemical characteristics”. Russia 2014-2015.
  • Participant of the grant of Russian Foundation for Basic Research № 13-03-00348 A. “Structural optimization of bicyclic non-aromatic derivatives of 2-amino-1,3-selenazines of neuroprotective and antioxidant action with the aim of correction of characteristics affecting bioavailability”. Russia 2013-2015.
  • Project manager of the grant of the President of Russian Federation. “Preparation of soluble forms of non-steroidal anti-inflammatory connections based on co-crystal technology”. Russia 2013-2014
The most important publications:

Monograph:

  1. Perlovich, G.L.; Surov, A.O.; Manin A.N. Pharmaceutical multi-component crystals: improving the efficacy of anti-tuberculous agents. In Multi-Component Crystals: Synthesis, Concepts, Function, Tiekink, E., Zukerman-Schpector, J., Ed.; De Gruyter, 2017, p. 32-59

 

Articles:

  1. Drozd K.V., Manin A.N., Perlovich G.L. Comparative analysis of experimental methods for determining thermodynamic parameters of formation of multi-component molecular crystals: Benefits and limitations. Journal of Molecular Liquids, 2019, 295, 111644. Doi: 10.1016/j.molliq.2019.111644
  2. Manin, A.N., Voronin, A.P., Drozd, K.V., Perlovich, G.L. Thermodynamic properties of Nalidixic and Oxolinic acids: Experimental and computational study. Thermochimica Acta, 2019, 682, 178411. Doi: 10.1016/j.tca.2019.178411
  3. Surov, A.O., Manin, A.N., Voronin, A.P., Boycov, D.E., Magdysyuk, O.V., Perlovich, G.L. New Pharmaceutical Cocrystal Forms of Flurbiprofen: Structural, Physicochemical, and Thermodynamic Characterization. Cryst. Growth Des., 2019, DOI: 10.1021/acs.cgd.9b00781
  4. Manin, A.N.; Drozd, K.V.; Churakov, A.V.; Perlovich, G.L. Design of 4-aminobenzoic acid two-component molecular crystals: prediction and experiments. CrystEngComm, 2019, 21(13), с. 2119-2129, doi: 10.1039/C8CE01857J.
  5. Manin, A.N.; Drozd, K.V.; Churakov, A.V.; Perlovich, G.L. Hydrogen Bond Donor/Acceptor Ratios of the Coformers: Do They Really Matter for the Prediction of Molecular Packing in Cocrystals? the Case of Benzamide Derivatives with Dicarboxylic Acids. Cryst. Growth Des., 2018, 18(9), 5254-5269.
  6. Manin, A.N.; Voronin, A.P.; Drozd, K.V.; Churakov, A.V.; Perlovich, G.L. Pharmaceutical salts of emoxypine with dicarboxylic acids. Acta Cryst. Sect. C: Struct. Chem., 2018, 74 (7), 797-806.
  7. Drozd, K.V., Manin, A.N., Churakov, A.V., Perlovich, G.L. Novel Drug-Drug Cocrystal of Carbamazepine with para-Aminosalicylic Acid: Screening, Crystal Structure and Comparative Study of Carbamazepine Cocrystals Formation Thermodynamics. CrystEngComm. 2017, 19, 4273-4286
  8. Surov, A. O., Manin, A. N., Voronin, A. P., Churakov, A. V., Perlovich, G. L., Vener, M. V. (2017). Weak Interactions Cause Packing Polymorphism in Pharmaceutical Two-Component Crystals. The Case Study of the Salicylamide Cocrystal. Crystal Growth & Design, 17 (3), 1425–1437
  9. Drozd, K.V.; Manin, A.N.; Churakov, A.V.; Perlovich, G.L. Drug-drug cocrystals of antituberculous 4-aminosalicylic acid: Screening, crystal structures, thermochemical and solubility studies. European Journal of Pharmaceutical Sciences, 2017, 99, 228-239
  10. Manin A. N.; Surov A. O.; Churakov A. V. and Perlovich G. L. Crystal Structures, Thermal Analysis and Dissolution Behavior of New Solid Forms of the Antiviral Drug Arbidol with Dicarboxylic Acids. Crystals, (2015), 5, 650-669
  11. Surov A. O.; Manin A. N.; Churakov A. V. and Perlovich G. L. New Solid Forms of the Antiviral Drug Arbidol: Crystal Structures, Thermodynamic Stability and Solubility. Molecular Pharmaceutics, (2015), 12 (11), 4154–4165
  12. Manin, A.N.; Voronin, A.P.; Shishkina, A.V.; Vener, M.V.; Churakov, A.V.; Perlovich, G.L. Influence of secondary interactions on the structure, sublimation thermodynamics, and solubility of salicylate:4-hydroxybenzamide cocrystals. Combined experimental and theoretical study. The Journal of Physical Chemistry B, (2015), 119(33), 10466-10477
  13. Surov A.O., Manin A.N., Voronin A.P., Drozd K.V., Simagina A.A., Churakov A.V., Perlovich G.L., Pharmaceutical salts of ciprofloxacin with dicarboxilic acids. European Journal of Pharmaceutical Sciences, 2015, 77, 112-121
  14. Surov, A.O.; Voronin, A.P.; Manin, A.N.; Manin, N.G.; Kuzmina, L.G.; Churakov, A.G.; Perlovich, G.L. Pharmaceutical Cocrystals of Diflunisal and Diclofenac with Theophylline. Mol. Pharmaceutics, 2014, 11 (10), 3707–3715.
  15. Manin, A.N.; Voronin, A.P.; Drozd, K.V.; Manin, N.G.; Bauer-Brandl, A.; Perlovich, G.L. Cocrystal screening of hydroxybenzamides with benzoic acid derivatives: A comparative study of thermal and solution-based methods. European Journal of Pharmaceutical Sciences, 2014, 65, 56-64
  16. Manin A.N., Voronin A.P., Manin N.G., Vener M.V., Shishkina A.V., Lermontov A.S., Perlovich G.L. Salicylamide cocrystals: Screening, crystal structure, sublimation thermodynamics, dissolution, and solid-state DFT calculation. The Journal of Physical Chemistry B, (2014), 118, 6803-6814
  17. Manin A.N., Voronin A.P., Perlovich G.L., Acetamidobenzoic acid isomers: Studying sublimation and fusion processes and their relation with crystal structures. Thermochimica Acta, (2014), 583, p. 72-77
  18. Perlovich G.L., Manin A.N. Design of Pharmaceutical cocrystals for drug solubility improvement. Russian Journal of General Chemistry, (2014), 84(2), 407-414
  19. Manin A.N., Voronin A.P., Perlovich G.L., Thermodynamic and structural aspects of hydroxybenzamide molecular crystal study. Thermochimica Acta, (2013), 551, p. 57-61
  20. Perlovich G.L., Manin A.N. Design of pharmaceutical cocrystals to improve drug solubility. Rossiiskii Khimicheskii Zhurnal, (2012), 56(3-4), 146-154
  21. Manin A.N., Shmukler L.E., Safonova L.P., Perlovich G.L. Partial molar volumes of some drug and prodrug substances in 1-octanol at 298.15 K. J. Chem. Thermodynamics (2010) 42:429-435.
  22. Perlovich G.L.; Volkova T.V.; Manin A. N.; Bauer-Brandl A. Influence of position and size of substituents on the mechanism of partitioning: a thermodynamic study on acetaminophens, hydroxybenzoic acids, and parabens. AAPS PharmSciTech (2008) 9(1):205-216.
  23. Perlovich G.L.; Volkova T.V.; Manin A. N.; Bauer-Brandl A. Extent and mechanism of solvation and partitioning of isomers of substituted benzoic acids: a thermodynamic study in the solid state and in solution. J. Pharm. Sci. (2008) 97(9):3883-3896.
  24. Perlovich G.L.; Hansen L.K.; Volkova T.V.; Mirza S.; Manin A. N.; Bauer-Brandl A. Thermodynamic and structural aspects of hydrated and unhydrated phases of 4-hydroxy-benzamide. Crystal Growth & Design. (2007) 7(12): 2643-2648.
  25. Manin N.G., Perlovich G.L., Manin A.N., Fini A. Thermodynamic of sodium diclofenac water solutions at 298.15-318.15 K. Russ. J. Phys. Chem. (2007), 81 (7), p.1212-1220
  26. Manin N.G., Fini A., Manin A.N., Perlovich G.L. Thermodynamics of sodium diclofenac salt aqueous solutions at various temperatures. J. Thermal Analysis and Calorimetry (2007) 90(1):147-152.

 

Patents

 

  1. Perlovich, G. L.; Manin, A. N.; Drozd, K. V. Co-crystalline form of isoniazid. Patent RU 2630957, Bulletin no 26, date of publishing: 15.09.2017
  2. Perlovich, G. L.; Manin, A. N.; Drozd, K. V. Diflunisal co-crystalline form. Patent RU 2617849, Bulletin no 13, date of publishing: 28.04.2017
  3. Perlovich G.L., Manin A.N., Manin N.G., Surov A.O., Voronin A.P. Cocrystalline form of theophylline with diflunisal or diclofenac. Patent RU 2542100, Bulletin no. 5 (2015), date of publishing: 20.02.2015
  4. Perlovich G.L., Manin A.N., Manin N.G., Voronin A.P. Cocrystalline form of 2-hydroxybenzamide with salicylic acid. Patent RU 2539350, Bulletin no. 2 (2015), date of publishing: 20.01.2015
  5. Perlovich G.L., Manin A.N., Manin N.G., Surov A.O., Voronin A.P. Cocrystalline forms of niflumic acid with isonicotinamide and caffeine. Patent RU 2536484, Bulletin no. 36 (2014), date of publishing: 27.12.2014
  6. Perlovich G.L., Manin A.N., Manin N.G., Voronin A.P. Cocrystalline form of fenbufen. Patent RU 2521572, Bulletin no. 18 (2014), date of publishing: 27.06.2014
  7. Perlovich, G. L.; Manin, A. N.; Manin, N. G.; Surov, A. O.; Ryzhakov, A. M. Method for obtaining the co-crystalline form of bicalutamide. Patent RU 2510392, Bulletin no. 9, date of publishing: 27.03.2014
  8. Perlovich G.L., Manin A.N., Manin N.G., Voronin A.P. Cocrystalline form of 2-hydroxybenzamide with 4-aminobenzoic acid. Patent RU 2497804, Bulletin no. 31 (2013), date of publishing: 10.11.2013
main stages of research and teaching:

2007 - 2008 - Laboratory Assistant Researcher, G.A. Krestov Institute of Solution Chemistry RAS.

2009 - 2010 - Intern researcher, G.A. Krestov Institute of Solution Chemistry RAS.

2010 - 2014 Junior Researcher, G.A. Krestov Institute of Solution Chemistry RAS.

2014 - 2019 – Researcher, G.A. Krestov Institute of Solution Chemistry RAS.

2019 - present - Senior Researcher, G.A. Krestov Institute of Solution Chemistry RAS.

 

Foreign internships:

 

July 2010 - Participation in the 14th International Symposium on Solubility Phenomena and Related Equilibrium Processes, Leoben, Austria

February 2013 - Internship at the University of Lille, Lille, France

March-April 2013 - internship at Syddansk Universitet, Odense, Denmark

August 2013 - participation in the international conference 44th World Chemistry Congress, Istanbul, Turkey.