Perlovich German Leonidovich

Position: 
Head of Department
Degree: 
Doctor of сhemical sciences
Academic title: 
professor
Phone: 
+7 (4932) 533784
E-mail: 
glp@isc-ras.ru
Subdivision: 
Laboratory of physical chemistry of drug compounds
Awards and honors:

  
Award of European Federation for Pharmaceutical Sciences for the Best paper published in European Journal of Pharmaceutics in 2003 year


Award of publishing house “ELSIVER” for the most cited paper in 2004 year published in European Journal of Pharmaceutics and Biopharmaceutics

 

Research interests:
  • Physical chemistry of solutions
  • Crystallochemistry
  • X-ray diffraction analysis of molecular crystals
  • Thermodynamics of sublimation, solubility and solvation processes of molecular crystals
  • Polymorphism
  • Distribution of drugs in biological relevant mediums
  • Passive transport of drug substances
  • Design of pharmaceutical systems for drug delivery
  • Pharmaceutical cocrystals
  • Development and design of High Throughput Screening (HTS) algorithms of membrane permeability of drug compounds
  • Development of High Throughput Screening (HTS) algorithms for cocrystal preparation

Specific:

  1. Sublimation thermodynamics of molecular crystals: temperature dependences of vapour pressure; thermodynamic functions; phase transitions (Effusion method and flow inert gas (transpiration) method, DSC).
  2. Crystal lattice energy calculation of molecular crystals (drugs, polymorphic phases) and solvates: analysis of various energetic packing terms, molecular conformational states into crystal lattice (MS Studio, PKSFX, XP, GSAS)
  3. Thermochemistry of dissolution process of molecular crystals in various organic solvents. Correlation analysis between the solution enthalpies and the physical-chemical properties of solvents (Solution Calorimetry).
  4. Thermodynamics of host-guest interaction in solutions: binding constants; Gibbs energy and enthalpy of binding; stoichiometry (Titration Calorimetry, NMR, spectrometry).
  5. Thermodynamics and kinetics of phase transitions: molecular crystals polymorphism (DSC, TG, Solution Calorimetry, X-ray, IR, Solubility).
  6. Thermochemistry and kinetics of desolvation processes of solvates (host-guest crystals, “sponges”). Investigation of the first order phase transition heat effects: polymorphism and pseudo-polymorphism of the solvates (DSC, TG, Solution Calorimetry, X-ray, IR, Solubility).
  7. X-ray powder diffraction investigations: calculation of the unit cell parameters and identification of reflection planes using the Ito algorithm.
  8. Thermodynamics of dissolution and solvation process of molecular crystals (drugs) in water, buffers and various organic solvents: specific and non-specific solvation; transfer thermodynamic functions; solvation shell (Isothermal saturation method, Solution Calorimetry).
  9. Thermodynamics of drugs distribution (partitioning) between two-unmixed phase (water-octanol, water-benzene).
  10. Investigation of volumetric properties of two- and three-component systems. Correlation analysis between the molecular conformation state (topology) and the partial molar volume.
  11. Drug delivery systems: cocrystals, solvates, supramolecular systems, cyclodextrins.
Participation in grants and programs:

Investigations were supported by:

  • The Russian Foundation for Basic Research
  • The Russian Scientific Foundation (№ 14-13-00640)
  • The Federal Agency for Science and Innovations (№ 02.740.11.0857; № 2012-1.4-12-000-1028-6539; № 14.616.21.0027)
  • The basic research programs established by the Presidium of Russian Academy of Sciences “Fundamental Sciences for Medicine”
  • The basic research programs established by the Presidium of Russian Academy of Sciences “Medical and Biomolecular Chemistry”
  • The presidium of Russian Academy of Sciences “Fundamental bases of nanostructures and nanomaterials technologies” (Subprogram: III. Nanobiotechnologies)
  • The Seventh Framework Program of the European Community for Research, Technological Development and Demonstration Activities (IRSES-GA-2009-247500)
  • Found for support of the national science at the nominations: “doctor of science”, “candidate of science”, “PhD student”

Bilateral agreements between Russia and:

  • Norway;
  • Italy;
  • Denmark;
  • Finland;
  • China;
The most important publications:

List of recent publications (2012 – 2015)

  1. Perlovich G.L., Ryzhakov A.M., Tkachev V.V., Proshin A.N. Adamantane Derivatives of Sulfonamide Molecular Crystals: Structure, Sublimation Thermodynamic Characteristics, Molecular Packing, Hydrogen Bonds Networks. CrystEngComm (2015) 17 (4), 753 – 763.
  2. Surov A.O., Simagina A.A., Manin N.G., Kuzmina L.G., Churakov A.V., Perlovich G.L. Fenamate Co-crystals with 4,4′-Bipyridine: Structural and Thermodynamic aspects. Crystal Growth & Design. (2015) 15(7), 228-238.
  3. Perlovich G.L., Kazachenko V.P., Strakhova N.N., Raevsky O.A. Impact of Sulfonamide Structure on Solubility and Transfer Processes in Biologically Relevant Solvents. J. Chem. Eng. Data (2014) 59(12), 4217-4226.
  4. Surov A.O., Voronin A.P., Manin A.N., Manin N.G., Kuzmina L.G., Churakov A.V., Perlovich G.L. Pharmaceutical co-crystals of diflunisal and diclofenac with theophylline. Mol. Pharmaceutics. (2014) 11(10), 3707-3715.
  5. Manin A.N., Voronin A.P., Drozd K.V., Manin N.G., Bauer-Brandl A., Perlovich G.L. Cocrystal screening of hydroxybenzamides with benzoic acid derivatives: A comparative study of thermal and solution-based methods. European Journal of Pharmaceutical Sciences (2014) 65, 56–64.
  6. Ol’khovich M.V., Sharapova A.V., Lavrenov S.N., Blokhina S.V., Perlovich G.L. Inclusion complexes of hydroxypropyl-b-cyclodextrin with novel cytotoxic compounds: Solubility and thermodynamic properties. Fluid Phase Equilibria (2014) 384, 68–72.
  7. Manin A.N., Voronin A.P., Manin N.G., Vener M.V., Shishkina A.V., Lermontov A.S., Perlovich G.L. Salicylamide Cocrystals: Screening, Crystal Structure, Sublimation Thermodynamics, Dissolution, and Solid-State DFT Calculations. J. Phys. Chem. B (2014) 118 (24), 6803-6814.
  8. Surov A.O., Solanko K.A., Bond A.D., Bauer-Brandl A., Perlovich G.L. Polymorphism of felodipine co-crystals with 4,4′-bipyridine. CrystEngComm (2014) 16, 6603-6611.
  9. Manin A.N., Voronin A.P., Perlovich G.L. Acetamidobenzoic acid isomers: Studying sublimation and fusionprocesses and their relation with crystal structures. Thermochimica Acta (2014) 583, 72– 77.
  10. Surov A.O., Proshin A.N., Perlovich G.L. Crystal structure analysis and sublimation thermodynamics of bicycle derivatives of a neuroprotector family. Acta Cryst. (2014) B70, 47-53.
  11. Perlovich G.L. Thermodynamic Approaches to the Challenges of Solubility in Drug Discovery and Development. Mol. Pharmaceutics. (2014) 11(1), 1-11.
  12. Perlovich G.L. Thermodynamic approach to improving solubility prediction of co-crystals in comparison with individual poorly soluble components. J. Chem. Thermodynamics (2014), 73, 85-89.
  13. Blokhina S.V., Ol’khovich M.V., Sharapova A.V., Perlovich G.L., Proshin A.N. Vapor pressures and sublimation enthalpies of novel bicyclic heterocycle derivatives. J. Chem. Thermodynamics (2014) 69, 107-111.
  14. Blokhina S.V., Ol’khovich M.V., ., Sharapova A.V., Volkova T.VProshin A.N., Perlovich G.L. Effect of the structure, solid state and lipophilicity on the solubility of novel bicyclic derivatives. J. Chem. Thermodynamics (2014) 78, 152-158.
  15. Blokhina S.V., Volkova T.V., Ol’khovich M.V., Sharapova A.V., Proshin A.N., Perlovich G.L. Solubility and solution thermodynamics of novel bicyclic derivatives of 1,3-selenazine in biological relevant solvents. J. Chem. Eng. Data (2014) 59(7), 2298-2304.
  16. Blokhina S.V., Ol’khovich M.V., Sharapova A.V., Volkova T.V., Proshin A.N., Bachurin S.O., Perlovich G.L. Synthesis, Biological Activity, Distribution and Membrane Permeability of Novel Spiro-thiazines as Potent Neuroprotectors. Eur. J. Med. Chem. (2014) 77, 8-17.
  17. Perlovich G.L., Ryzhakov A.M., Strakhova N.N., Kazachenko V.P., Schaper K.-J., Raevsky O.A. Thermodynamic aspects of solubility and partitioning processes of some sulfonamides in the solvents modeling biological media. J. Chem. Thermodynamics (2014) 69, 56-65.
  18. Surov A.O., Cong Trinh Bui, Proshin A.N., Roussel P., Idrissi A., Perlovich GL. Novel 1,2,4-Thiadiazole Derivatives: Crystal Structure, Conformational Analysis, Hydrogen Bond Networks, Calculations, and Thermodynamic Characteristics of Crystal Lattices. J. Phys. Chem. B (2013) 117, 10414−10429.
  19. Perlovich G.L., Blokhina S.V., Ol’khovich M.V., Sharapova A.V., Proshin A.N. Solubility, Solvation and Distribution of Novel Spiro-Derivatives of 1,3-Thiazine in Aqueous and Organic Solutions. J. Solution Chem. (2013) 42 (10), 2057-2069.
  20. Ol’khovich M.V., Blokhina S.V., Sharapova A.V., Perlovich G.L., Proshin A.N. Thermodynamics of sublimation and solvation for bicyclo-derivatives of 1,3-thiazine. Thermochimica Acta (2013) 569, 61– 65.
  21. Blokhina S.V., Ol’khovich M.V., Sharapova A.V., Proshin A.N., Perlovich G.L. Partition Coefficients and Thermodynamics of Transfer of Novel Drug-like Spiro-derivatives in Model Biological Solutions. J. Chem. Thermodynamics (2013) 61, 11–17.
  22. Perlovich G.L., Ryzhakov A.M., Tkachev V.V., Hansen L.Kr., Raevsky O.A. Sulfonamide Molecular Crystals: Structure, Sublimation Thermodynamic Characteristics, Molecular Packing, Hydrogen Bonds Networks. Crystal Growth & Design. (2013) 13(9):4002-4016.
  23. Perlovich G.L., Kazachenko V.P., Strakhova N.N., Schaper K.-J., Raevsky O.A. Solubility and Transfer Processes of Some Hydrazones in Biologically Relevant Solvents. J. Chem. Eng. Data (2013) 58(9), 2659-2667.
  24. Surov А.O., Solanko K.A., Bond A.D., Bauer-Brandl A., Perlovich G.L. Crystal architecture and physicochemical properties of felodipine solvates. CrystEngComm (2013) 15 (30), 6054 – 6061.
  25. Perlovich G.L., Proshin A.N., Ol’khovich M.V., Sharapova A.V., Lermontov A.S. Novel Spiro-Derivatives of 1,3-Thiazine Molecular Crystals: Structural and Thermodynamic Aspects. Crystal Growth & Design. (2013) 13(2):804-815.
  26.  Manin N.G., Perlovich G.L., Fini A. Thermochemical study of aqueous solutions of lithium diclofenac at 293.15-318.15 K. Russian Journal of Physical Chemistry A, 2013, 87(4), 580-588.
  27. Manin A.N., Voronin A.P., Perlovich G.L. Thermodynamic and structural aspects of hydroxybenzamide molecular crystals study. Thermochimica Acta (2013) 551:57-61.
  28. Perlovich G.L., Blokhina S.V., Manin N.G., Volkova T.V., Tkachev V.V. Polymorphism and Solvatomorphism of Bicalutamide: Thermophysical Study and Solubility. J. Thermal Analysis and Calorimetry (2013) 111:655-662.
  29. Solanko K.A., Surov A.O., Perlovich G.L., Bauer-Brandl A., Bond A.D. Felodipine–diazabicyclo[2.2.2]-octane–water (1/1/1). Acta Cryst. (2012) C68:o1–o3.
  30. Perlovich G.L., Blokhina S.V., Manin N.G., Volkova T.V., Tkachev V.V. Polymorphs and solvates of felodipine: Analysis of crystal structures and thermodynamic aspects of sublimation and solubility processes. CrystEngComm (2012) 14:8577-8588.
  31. Ol’khovich M.V., Sharapova A.V., Blokhina S.V., Perlovich G.L., Proshin A.N. Vapor Pressures and Sublimation Thermodynamic Parameters for Novel Drug-Like Spiro-Derivatives. J. Chem. Eng. Data (2012) 57:3452-3457.
  32. Surov A.O., Solanko K.A., Bond A.D., Perlovich G.L., Bauer-Brandl A. Crystallization and Polymorphism of Felodipine. Crystal Growth & Design. (2012) 12(8):4022-4030.
  33. Blokhina S.V., Ol’khovich M.V., Sharapova A.V., Proshin A.N., Perlovich G.L. Thermodynamics of Solubility Processes of Novel Drug-like Spiro-Derivatives in Model Biological Solutions. J. Chem. Eng. Data (2012) 57(7):1996-2003.
  34. Perlovich G.L., Proshin A.N., Volkova T.V., Petrova L.N., Bachurin S.O. Novel 1,2,4-Thiadiazole Derivatives as Potent Neuroprotectors: Approach to Creation of Bioavailable Drugs. Mol. Pharmaceutics (2012) 9(8):2156-2167.
main stages of research and teaching:

2013 – Professor in “Physical Chemistry”

2001 – D.Sc. examination in “Physical Chemistry” at the Institute of Solution Chemistry, Ivanovo, Russia. Thesis title: “Physical-chemical properties of porphyrin solutions and porphyrins molecular crystals.”

1991 – Ph.D. (Cand.Sci.) examination in “Physical Chemistry” at the Institute of Solution Chemistry (former Institute of Non-Aqueous Solution Chemistry), Ivanovo, Russia. Thesis title: “Thermochemical characteristics of solution and solvation processes of oxybenzenes and its derivatives in organic solvents”.

1984 – Master of Science examination in “Physical Chemistry” at the Moscow Steel and Alloys Institute, Department of Physical Chemistry, Russia

Career/Employment:

2010 – present – Leader of the Laboratory

2004 – 2010 - Institute of Solution Chemistry of the Russian Academy of Science, Ivanovo, Russia. Principal Scientist.

2002 – 2004 - Institute of Solution Chemistry of the Russian Academy of Science, Ivanovo, Russia. Leader Scientist.

1994 – 2002 - Institute of Solution Chemistry of the Russian Academy of Science, Ivanovo, Russia. Senior Scientist.

1991 – 1994 - Institute of Non-Aqueous Solution Chemistry of the Russian Academy of Science, Ivanovo, Russia. Scientist.

1989 – 1991 - Institute of Non-Aqueous Solution Chemistry of the Russian Academy of Science, Ivanovo, Russia. Post-graduate student.

1984 – 1989 - Institute of Solid State Physics of the Russian Academy of Science, Chernogolovka, Russia. Engineer-investigator.

 

Work and Stages in Research Centers:

1995 – 2000 - Institute of Physical Chemistry of the Polish Academy of Science, Department of Calorimetry, Warsaw, Poland. Invited researcher.

2000 – 2008 - Institute of Pharmacy, University of Tromsø, Department of Pharmaceutics and Bio Pharmaceutics, Tromsø, Norway. Invited researcher.

2010 –           Max-Plank-Institute of Applied Mathematics. Leipzig. Germany.

2012 –           Institute of Physics and Chemistry, University of Southern Denmark, Odense, Denmark.

2014 –           Chemistry Department, LASIR, UMR 8516 University des Sciences et Technologies de Lille-1.