Manin Alex Nikolaevich

Position: 
Researcher
Degree: 
Phd in chemistry
Phone: 
+7 (4932) 336990
Awards and honors:
  1. IUPAC Poster prize at the 14th International symposium on Solubility Phenomena & Related Equilibrium Phenomena (ISSP-14), Leoben, Austria, 2010.
  2. First prize on V Regional young scientist conference. G.A. Krestov Institute of Solution Chemistry, Russian Academy of Sciences, Ivanovo, Russia, 2010
  3. First prize students and post-graduate students research works competition for research work “Pharmaceutical cocrystal screening optimization”, Moscow, 2010
  4. Acknowledgement from organizers for an active participation on the VI International Conference “Kinetics and crystallization mechanism. Self-organization by phase formation”, Russia, 2010
  5. 1st degree poster prize on V all-russian conference of students and post-graduate students with international participation “Chemistry in modern world”, Saint-Petersburg, 2011.
  6. Scholarship of Academician G. N. Krestov, G.A. Krestov Institute of Solution Chemistry, Russian Academy of Sciences. 2010
  7. First prize on Students and post-graduate students all-Russian competition of research in the field of chemistry and material sciences in the National Festival of Science, Kazan for research work “Development of promising drugs with improved solubility by cocrystallization technology”, 2011
  8. First prize, XI International conference “Problem of solvation and complex formation in solutions”; VI Young scientist conference. G.A. Krestov Institute of Solution Chemistry, Russian Academy of Sciences, Ivanovo, Russia, 2011
  9. First prize on VIII Regional young scientist conference. G.A. Krestov Institute of Solution Chemistry, Russian Academy of Sciences, Ivanovo, Russia, 2013
His research interests:
  • Design of molecular co-crystals on basis of drug molecules and investigation their physicochemical properties.
  • Thermodynamics of dissolution process of molecular crystals (drugs) in water, buffer solutions and various organic solvents (Isothermal saturation method).
  • Partitioning and distribution of drugs in water-octanol system;
  • Thermodynamics of fusion and vaporization, heat capacity determination using thermogravimetric (TG) and DSC techniques.
  • Sublimation thermodynamics of molecular crystals (drugs): vapour pressure; thermodynamic functions (The flow inert gas (transpiration) method).
Participation in grants and programs:
  • The Russian Foundation for Basic Research (№14-03-01031 А (2014-2016); №14-03-00009 А. (2014-2016); №14-03-31001 mol_a (2014-2015); № 13-03-00348 А. (2013-2015); 09-03-00057-а. (2009-2011); № 10-03-09286 – mob_z. (2010);
  • Grant of the President of the Russian Federation for young scientists (МК-2013; MK-2012)
  • The Seventh Framework Program of the European Community for Research, Technological Development and Demonstration Activities (IRSES-GA-2009-247500) 2010-2013
  • The Federal Agency for Science and Innovations  № 02.740.11.0857.(2010-2012) (исполнитель)
  • The presidium of Russian Academy of Sciences “Fundamental bases of nanostructures and nanomaterials technologies” (Subprogram: III. Nanobiotechnologies)
The most important publications:
  1. Manin, A.N.; Voronin, A.P.; Shishkina, A.V.; Vener, M.V.; Churakov, A.V.; Perlovich, G.L. Influence of secondary interactions on the structure, sublimation thermodynamics, and solubility of salicylate:4-hydroxybenzamide cocrystals. Combined experimental and theoretical study. The Journal of Physical Chemistry B, (2015), 119(33), 10466-10477
  2. Surov A.O., Manin A.N., Voronin A.P., Drozd K.V., Simagina A.A., Churakov A.V., Perlovich G.L., Pharmaceutical salts of ciprofloxacin with dicarboxilic acids. European Journal of Pharmaceutical Sciences, 2015, 77, 112-121
  3. Artem O. Surov, Alexander P. Voronin, Alex N. Manin, Nikolay G. Manin, Lyudmila G. Kuzmina, Andrei V. Churakov, and German L. Perlovich. Pharmaceutical Cocrystals of Diflunisal and Diclofenac with Theophylline. Mol. Pharmaceutics, 2014, 11 (10), pp 3707–3715.
  4. Alex N. Manin, Alexander P. Voronin, Ksenia V. Drozd, Nikolay G. Manin, Annette Bauer-Brandl, German L. Perlovich. Cocrystal screening of hydroxybenzamides with benzoic acid derivatives: A comparative study of thermal and solution-based methods. European Journal of Pharmaceutical Sciences, 2014, 65, 56-64
  5. Manin A.N., Voronin A.P., Manin N.G., Vener M.V., Shishkina A.V., Lermontov A.S., Perlovich G.L. Salicylamide cocrystals: Screening, crystal structure, sublimation thermodynamics, dissolution, and solid-state DFT calculation. The Journal of Physical Chemistry B, (2014), 118, 6803-6814
  6. Manin A.N., Voronin A.P., Perlovich G.L., Acetamidobenzoic acid isomers: Studying sublimation and fusion processes and their relation with crystal structures. Thermochimica Acta, (2014), 583, p. 72-77
  7. Perlovich G.L., Manin A.N. Design of Pharmaceutical cocrystals for drug solubility improvement. Russian Journal of General Chemistry, (2014), 84(2), 407-414
  8. Manin A.N., Voronin A.P., Perlovich G.L., Thermodynamic and structural aspects of hydroxybenzamide molecular crystal study. Thermochimica Acta, (2013), 551, p. 57-61
  9. Перлович Г.Л., Манин А.Н. Дизайн фармацевтических сокристаллов с целью повышения растворимости лекарственных соединений. Российский химический журнал, 2012, LVI (3-4), 146-154
  10. Manin A.N., Shmukler L.E., Safonova L.P., Perlovich G.L. Partial molar volumes of some drug and prodrug substances in 1-octanol at 298.15 K. J. Chem. Thermodynamics (2010) 42:429-435.
  11. Perlovich G.L.; Volkova T.V.; Manin A. N.; Bauer-Brandl A. Influence of position and size of substituents on the mechanism of partitioning: a thermodynamic study on acetaminophens, hydroxybenzoic acids, and parabens. AAPS PharmSciTech (2008) 9(1):205-216.
  12. Perlovich G.L.; Volkova T.V.; Manin A. N.; Bauer-Brandl A. Extent and mechanism of solvation and partitioning of isomers of substituted benzoic acids: a thermodynamic study in the solid state and in solution. J. Pharm. Sci. (2008) 97(9):3883-3896.
  13. Perlovich G.L.; Hansen L.K.; Volkova T.V.; Mirza S.; Manin A. N.; Bauer-Brandl A. Thermodynamic and structural aspects of hydrated and unhydrated phases of 4-hydroxy-benzamide. Crystal Growth & Design. (2007) 7(12): 2643-2648.
  14. Manin N.G., Perlovich G.L., Manin A.N., Fini A. Thermodynamic of sodium diclofenac water solutions at 298.15-318.15 K. Russ. J. Phys. Chem. (2007), 81 (7), p.1212-1220
  15. Manin N.G., Fini A., Manin A.N., Perlovich G.L. Thermodynamics of sodium diclofenac salt aqueous solutions at various temperatures. J. Thermal Analysis and Calorimetry (2007) 90(1):147-152.